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The depletion method is associated with higher risks of injury and fatigue due to its methodology, which involves a phase of severe carbohydrate restriction followed by a reloading phase. During the depletion phase, athletes significantly reduce their carbohydrate intake, which can lead to low muscle glycogen levels. This state of glycogen depletion can contribute to fatigue, decreased performance, and a greater likelihood of muscle injury, especially as the body is subjected to intense training or competition during this period.

Furthermore, the abrupt transition from carbohydrate restriction to supercompensation can overwhelm the body if not managed carefully, resulting in symptoms of fatigue and a heightened risk of injury during the reloading phase. The other methods listed either involve a more gradual tapering or constant high carbohydrate intake, which maintains energy levels and minimizes the risk of overtraining and injuries.