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The best choice for yielding the most protein per serving by weight is isolated protein. Isolated protein products are processed to remove most fats and carbohydrates, resulting in a higher concentration of protein. They typically undergo additional filtration to eliminate non-protein constituents, which can allow for protein content that exceeds 90% by weight in some cases.

In contrast, concentrates generally contain around 70-80% protein by weight and may include more fats and carbohydrates. Filtered sources, while generally having a higher protein content than whole foods, can be less concentrated than isolated protein. Whole food sources usually provide protein alongside other macronutrients and micronutrients, leading to lower protein content per gram when compared with isolated forms. Therefore, isolated protein is the optimal choice when specifically looking for the highest protein content per weight measurement.